Abstract
Nimbidin, an ester of terpenic origin, which forms the major bitter principle isolated
from the oil of seed scernels of Azadirachta indica (Meliaceae) was found to possess significant anti-ulcer potential in various experimental
models. Anti-ulcer studies (preventive tests) revealed very significant protective
effect of the test drug in doses of 20 to 40 mg/kg (p.o.) in acetylsalicylic acid,
stress, serotonin and indomethacin induced gastric lesions in rats. The test drug
also afforded remarkable protection in both types of chemically induced duodenal lesions
in rodents. In ulcer healing tests, nimbidin significantly enhanced the healing process
in acetic acid induced chronic gastric lesions in albino rats and dogs.
